Longtime actor and comedian Jerry Lewis has died early Sunday morning, his family said.

“Famed comedian, actor and legendary entertainer Jerry Lewis passed away peacefully today of natural causes at 91 at his home in Las Vegas with his family by his side,” the Lewis family said in a statement to Reuters.

Lewis faced many health problems throughout the years, including prostate cancer and two heart attacks.

Lewis went on to star in, produce and direct an array of films, including “The Delicate Delinquent”, “The Bellboy” and “The Nutty Professor”.

Despite ups and downs, Lewis continued to work, performing onstage and even directing a musical theatre version of “The Nutty Professor” at the Tennessee Performing Arts Center in Nashville in 2012.

Josh Gad called Lewis, “One of the greatest of all time.”

Lewis, who was formerly married to Patti Palmer, is survived by his wife, SanDee Pitnick, and his children, sons Gary, Ronnie, Scott, Christopher and Anthony and daughter Danielle.